Cisplatin and kidney injury

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August undefined, 2024

WebDec 2, 2024 · It is well recognized that cisplatin may induce acute kidney injury (AKI) during chemotherapy. However, recent work further indicates that cisplatin treatment may have long-term effects in kidneys resulting in the development or progression of chronic kidney disease (CKD) in treated patients ( 16 ). WebOct 14, 2024 · Cisplatin effectiveness is reduced by its dose-limiting nephrotoxicity. Approximately 30% of patients administered cisplatin develop AKI.2There are no …

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WebDec 21, 2024 · myo -inositol; cisplatin; acute kidney injury; ferroptosis 1. Introduction Acute kidney injury (AKI) is an ominous clinical–pathologic state associated with the abrupt loss of renal functions and consequential complications. It is estimated that more than 20–50% of hospitalized patients are affected by various episodes of AKI [ 1 ]. WebJan 3, 2024 · All of these drugs can affect the glomerulus, tubules, interstitium, or renal microvasculature via different mechanisms, with clinical manifestations that range from an asymptomatic elevation of serum creatinine and electrolyte disorders to acute kidney injury requiring dialysis. how to set up xbox controller cemu

Rapamycin Perfluorocarbon Nanoparticle Mitigates Cisplatin …

WebSurgery-induced renal ischemia and reperfusion (I/R) injury and nephrotoxic drugs like cisplatin can cause acute kidney injury (AKI), for which there is no effective therapy. Lipid accumulation is evident following AKI in renal tubules although the mechanisms and pathological effects are unclear. Here, we report that Ehmt2-encoded histone ... WebMay 8, 2024 · Additionally, patients who did not receive mannitol with cisplatin were 2.6 times more likely to develop acute kidney injury. Implications for Practice. Overall, Duffy et al. said that the evidence regarding interventions to prevent nephrotoxicity is still limited and unable to support best practices for patients. They called for additional ... WebRT @NatMetabolism: RESEARCH From Tomohito Doke et al. (@Penn): NMN & NR supplementation has protective effects on kidney injury by preventing cisplatin-induced … how to set up xbox cloud gaming on chromebook

Acute kidney injury during cisplatin therapy and ... - Springer

Cisplatin-Associated Nephrotoxic Effects in Children Acute Kidney ...

WebNov 1, 2024 · Cisplatin is a widely used chemotherapeutic drug with notorious toxicity in the kidneys, which involves mitochondrial dysfunction and damage in renal tubular cells. Mitophagy is a form of... WebDec 21, 2024 · The clinical use of cisplatin has been hampered by its dose-dependent side effects, e.g., nephrotoxicity, and the precise mechanism(s) related to such a cisplatin … notho korthausaeWebDec 3, 2024 · In a new paper accepted for publication in the Journal of the American Society of Nephrology, researchers at Yale School of Medicine share findings that indicate that, for the first time, there is a potential renal targeted treatment for kidney injury caused by cisplatin, a widely used anti-cancer drug. notho guentheri

"WebSep 15, 2024 · Cisplatin is the prototype platinum coordination complex classified as an alkylating agent and used intravenously in the treatment of several forms of cancer. Cisplatin has been associated with a low rate of serum enzyme elevations and with rare cases of clinically apparent, acute liver injury. " - Cisplatin and kidney injury

Cisplatin and kidney injury

WebApr 11, 2024 · NAD+ precursor supplementation prevents mtRNA/RIG-I-dependent inflammation during kidney injury. Nature Metabolism - Doke et al. show that NMN and … WebOct 19, 2024 · Background. Few studies describe acute kidney injury (AKI) burden during paediatric cisplatin therapy and post-cisplatin kidney outcomes. We determined risk …

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WebMar 20, 2024 · The reality of cisplatin-induced acute kidney injury (CIA) and its effects on long-term renal function remain unclear. The aim of this study was to investigate the incidence and risk factors for CIA development, and if CIA is a useful predictor of long-term renal dysfunction after cisplatin treatment. Methods WebSep 2, 2024 · MLT alleviates cellular apoptosis after kidney injury caused by cisplatin, inhibiting the NF-κB–mediated inflammatory response and RIPK1/RIPK3 complex–mediated necroptosis (Kim et al., 2024). Meanwhile, MLT increases the expression of an anti-aging protein, Koltho, and prevents cellular apoptosis, resulting in maintaining the renal ...

WebJul 22, 2024 · Exposure of tubular cells to cisplatin activates complex signaling pathways that result in tubular cell injury and cell death. A robust inflammatory response, as well … WebCisplatin is an antitumor drug used in the treatment of a wide variety of malignancies. However, its primary dose-limiting side effect is kidney injury, which is a major clinical concern. To help understand mechanisms involved in the development of kidney injury, cisplatin rodent model has been developed. Given the complex pathogenesis of kidney …

WebAims: This study investigated the regulatory effect of Mitofusin2 (Mfn2) on mitochondria-associated endoplasmic reticulum membrane (MAMs) integrity and cellular injury in cisplatin-induced acute kidney injury (CP-AKI). Results: CP- AKI mice exhibited decreased expression of Mfn2, increased expression of phosphorylated adenosine … WebJan 28, 2024 · A major adverse consequence of cisplatin therapy is acute kidney injury (AKI). It is reported that between 30 and 38 percent of patients develop signs of nephrotoxicity (toxicity in the kidneys) after a single cisplatin dose, despite strategies such as hydration to limit renal exposure. This is problematic for patients as kidney injury can ...

WebApr 6, 2015 · Acute kidney injury (AKI) is a potentially fatal syndrome characterized by a rapid decline in kidney function caused by ischemic or toxic injury to renal tubular cells. The widely used chemotherapy drug cisplatin accumulates preferentially in the renal tubular cells and is a frequent cause of drug-induced AKI.

WebMar 29, 2024 · Administration of the chemotherapeutic agent cisplatin leads to acute kidney injury (AKI). Cisplatin-induced AKI (CIAKI) has a complex pathophysiological map, which has been linked to cellular … notho99WebA known complication of cisplatin administration is acute kidney injury (AKI). The nephrotoxic effect of cisplatin is cumulative and dose-dependent and often necessitates … how to set up xbox elite series 2 controllerWebOct 22, 2024 · Dose-dependent progression to CKD by repeated cisplatin administration. In order to evaluate the kidney injury after repeated injection of different doses of cisplatin in vivo, male wild type mice ... nothng ear 1WebTY - JOUR. T1 - Caught in the crossfire. T2 - cancer, cisplatin therapy, and kidney injury. AU - Humphreys, Benjamin D. PY - 2024/4/1. Y1 - 2024/4/1 how to set up xbox game barWebMar 27, 2024 · Cisplatin-induced acute kidney injury (AKI) is common during preoperative chemotherapy for esophageal cancer. The purpose of this study was to investigate the … nothoa benogayWebJan 29, 2024 · Fig. 1: Cisplatin induced Renal injury were alleviated by Ferroptosis inhibitor Ferrostatin-1 (Fer-1). A, B Serum BUN and Cr levels of each group at 48 h and 72 h after cisplatin injection. C... notho rubripinnisWebMay 18, 2024 · Vascular injuries caused by cisplatin may be due to an atypical hemolytic uremic syndrome. 58 Renal vascular pathology shows concentric subintimal thickening of small arteries and arterioles, with loose mucoid-appearing material and fibrin thrombi in afferent arterioles and glomerular capillaries. 58 From the age of 18 years to 80 years, … how to set up xbox live gold on xbox one