Cisplatin binding to holliday junction
WebMay 15, 2007 · This binding mode is specific for the Holliday junction and does not cause unwinding of the DNA helices. Citing Literature Supporting Information Volume 46, Issue …
Cisplatin binding to holliday junction
Did you know?
WebMar 15, 1997 · The results confirm that RuvC protein binds Holliday junctions as a dimer. Influence of DNA sequence on incision Previously it was shown that Holliday junction cleavage by RuvC occurs at specific sequences, with the consensus defined as 5′- A / T TT ↓G / C -3′. Single base changes within this sequence severely reduce the efficiency of … WebFour-way DNA intermediates, called Holliday junctions (HJs), can form during meiotic and mitoticrecombination,andtheirremovaliscrucialforchromosomesegregation.Agroupof ubiquitous and highly specialized structure-selective endonucleases catalyze the cleavage of HJs into two disconnected DNA duplexes in a reaction called HJ resolution.
WebThe BCDX2 complex also bound to the synthetic Holliday junction, and its af®nity to the Holliday-junction DNA was signi®cantly higher than that of Rad51B (Fig. 4). WebStudy with Quizlet and memorize flashcards containing terms like The zipper-like connection between paired homologs in early prophase is known as a, Crossing-over takes place in bivalents (tetrads) consisting of ______ chromatids, and one crossover involves _______ chromatids., Which type of tetrad contains two recombinant and two parental …
WebNational Center for Biotechnology Information WebFeb 21, 1997 · The E. coli RuvA and RuvB proteins, which are involved in the late stages of recombination and the recombinational repair of damaged DNA, bind to Holliday junctions and promote branch migration. We have used electron microscopy and image analysis to examine RuvA and RuvB bound to model Holliday structures.
WebJan 4, 2024 · Organometallic Pillarplexes that bind DNA 4-way Holliday Junctions and Forks bioRxiv. bioRxiv posts many COVID19-related papers. A reminder: they have not …
WebApr 3, 2007 · The bifunctional binding of the anticancer drug cisplatin to two adjacent nucleobases in DNA is modeled using density functional theory. Previous experimental studies revealed that cisplatin binding to adjacent guanine and adenine is sensitive to nucleobase sequence. north carolina beach homes for sale cheapWebPMID: 9535214 Abstract Proteins that can be shown to strongly bind in vitro to the four-way (Holliday) junction DNA include not only the obvious candidates such as enzymes involved in recombination, but also a remarkably diverse group of seemingly unrelated proteins. how to request a state pension statementWebFrom PDB: 3CRX . Schematic diagrams of the three base-stacking conformational isomers of the Holliday junction. The two stacked conformers differ in which sets of two arms are … how to request a special phone numberWebway DNA structure, also called a Holliday junction, which is processed by the RuvABC proteins.2 The RuvA protein initially binds the Holliday junction, and then recruits RuvB protein rings to opposite sides of the junction.3,4 RuvB is a molecular motor that uses the energy derived from ATP binding and hydrolysis to drive unidirectional movement ... north carolina beach hotel dealsWebAug 5, 2011 · Holliday junctions are formed during recombination, double-strand break repair, and fork reversal during replication. Resolving Holliday junctions is a critical process for maintaining genomic stability [ 25, 26 ]. These junctions are resolved by a class of structure-specific nucleases: the junction-resolving enzymes. Figure 1 north carolina beach internshipsWebAug 27, 2024 · Brogden, A.L.; Hopcroft, N.H.; Searcey, M.; Cardin, C.J. Ligand bridging of the DNA Holliday junction: Molecular recognition of a stacked-X four-way junction by a … north carolina beach nourishmentWebK Komori, S Sakae, H Shinagawa, K Morikawa, Y Ishino, A Holliday junction resolvase from Pyrococcus furiosus: Functional similarity to Escherichia coli RuvC provides … north carolina beach house rentals with pool