Ctcf and ctcfl in cancer

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August undefined, 2024

WebApr 18, 2024 · In cancer, CTCF binding is disrupted through various mechanisms, such as DNA copy number alterations spanning domain boundaries 13, microdeletions within CBSs 13, and hypermethylation of CBSs 14 ... WebNov 2, 2024 · However, in cancer, CTCF is substituted by CTCFL/BORIS, depicted as a blue circle, shutting down the transcription of these tumor suppressor genes through activation of anti-sense transcripts. The …

Cancer-specific CTCF binding facilitates oncogenic …

WebMay 11, 2024 · Ubiquitously expressed CTCF is involved in numerous cellular functions, such as organizing chromatin into TAD structures. In contrast, its paralog, CTCFL, is normally only present in the testis. However, it is also aberrantly expressed in many cancers. While it is known that shared and unique zinc finger sequences in CTCF and CTCFL … WebCTCFL; Zinc finger protein CTCF-T; cancer/testis antigen 27; dJ579F20.2; Description CTCFL, a testis-specific DNA binding protein containing 11 C2H2-type zinc fingers, … iron horse helotes

PRAME and CTCFL-reactive TCRs for the treatment of ovarian cancer

WebJun 15, 2005 · Abstract. CTCF is a candidate tumor suppressor gene encoding a multifunctional transcription factor. Surprisingly for a tumor suppressor, the levels of CTCF in breast cancer cell lines and tumors were found elevated compared with breast cell lines with finite life span and normal breast tissues. In this study, we aimed to investigate the … WebOct 1, 2024 · Using the Kaplan Meier plotter the prognostic significance of mRNA levels of CTCFL in gastric, breast, and ovarian cancer were interrogated, similarly to the respective levels of CTCF. In gastric cancer high CTCFL mRNA expression levels are associated with worse OS compared with gastric cancers having low CTCFL mRNA expression (HR = … WebMay 11, 2024 · Ubiquitously expressed CTCF is involved in numerous cellular functions, such as organizing chromatin into TAD structures. In contrast, its paralog, CTCFL, is … port of peri peri south bend

(PDF) Pan-cancer analysis and experimental validation of DTL as a ...

Cancer-specific CTCF binding facilitates oncogenic transcriptional ...

WebSep 15, 2024 · Specific CTCF binding events occur in human cancers. Cancer-specific CTCF binding can be induced by other transcription factors to regulate oncogenic gene … WebJun 23, 2024 · The past and present efforts to combine CTCF studies with CTCFL/BORIS research are designed to emphasize Normal and … iron horse hobby waite park mnWebjayreese: Regen BioPharma Acquires Issued Patent and Preclinical Data Package for Targeting Cancer Stem Cell Regen Has Raised Almost $700,000 From "Angel" In... port of peri peri plano tx

"WebApr 1, 2024 · In this regard, BORIS (CTCFL), a CTCF paralog, is a promising cancer biomarker that is overexpressed and controls transcription in several cancer types, mainly in OC. " - Ctcf and ctcfl in cancer

Ctcf and ctcfl in cancer

CTCF shapes chromatin by multiple mechanisms: the impact …

WebThe LOF of CTCF or cohesin in cancer may cause activation of oncogenes through altering chromatin loops (Fig. 4). CTCF is frequently mutated in endometrial carcinoma, head … WebAug 7, 2024 · Main. Unlike CTCF, which is uniformly expressed in healthy tissues and cancer cells, the expression of BORIS is typically restricted to the testis 6 and embryonic stem cells 11 (Extended Data Fig ...

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WebNov 15, 2013 · Estrogens play a key role in breast cancer, with 60-70% of the cases expressing estrogen receptors (ERs), which are encoded by the ESR1 gene. CTCFL, a paralogue of the chromatin organizer CTCF, is a potential biomarker of breast cancer, but its expression in this disease is currently controversial. A positive correlation has been … WebSep 15, 2024 · Background: The three-dimensional genome organization is critical for gene regulation and can malfunction in diseases like cancer. As a key regulator of genome …

WebMay 4, 2024 · In recent years, the most extensively studied disease related to CTCF protein is cancer. Debaugny and Skok reviewed the oncogenic roles of CTCF and CTCFL (CTCF-like or BORIS; the paralog of CTCF, see below section for BORIS). Human IDH gene mutant gliomas exhibit DNA hypermethylation, which ... WebAug 4, 2024 · Pancreatic cancer’s poor prognosis is caused by distal metastasis, which is associated with epigenetic changes. However, the role of the 3D epigenome in pancreatic cancer biology, especially its metastasis, remains unclear. ... Notably, all sets of NDRs had CTCF and CTCFL motifs, which was consistent with the fact that CTCF is a vital ...

WebCTCF-mediated enhancer blocking is conserved from Drosophila to man (Moon et al. 2005) Antisense transcription of triplet repeats is constrained by CTCF (Cho et al. 2005) Boundaries between X inactivation and escape of inactivation bind CTCF (Filippova et al. 2005) CTCF antagonizes with CTCFL at the cancer testis gene MAGE-A1 (Vatolin et al. … WebCCCTC-binding factor ( CTCF ), an 11- zinc finger factor involved in gene regulation, utilizes different zinc fingers to bind varying DNA target sites. CTCF forms methylation-sensitive …

WebAug 12, 2024 · In this regard, BORIS (CTCFL), a CTCF paralog, is a promising cancer biomarker that is overexpressed and controls …

WebApr 4, 2024 · CTCF provided by HGNC Official Full Name CCCTC-binding factor provided by HGNC Primary source HGNC:HGNC:13723 ... LncRNA PCGEM1 promotes colorectal cancer cell proliferation and migration in positive feedback loop through PCGEM1/miR-433-3p/CTCF axis. ... CTCFL paralog. NCBI Reference Sequences (RefSeq) Go to the top of … iron horse haulingWebMar 20, 2024 · As CTCF is a significantly mutated gene in endometrial cancer, we sequenced CTCF in five endometrial cancer cell lines and identified four mutations (Figures 1a and c). port of peri peri frisco txWebCancer remains the main cause of human death worldwide, and most cancers still lack effective prevention and treatment means ... that DTL interacted with arsenic trioxide, aflatoxin b1, MLN7243 and palmitic acid. In addition, NRF1, E2F4, STAT3, CTCF, CTCFL and E2F1 were predicted to be the interacting targets. Hsa-miR-330-3p, hsa-miR ... iron horse hobbyWebFeb 7, 2024 · The oncogene CTCFL (BORIS), the paralog of CTCF, is a transcriptional factor highly expressed in ovarian cancer (but in rarely any other tissue in females) with cancer-specific characteristics and ... iron horse horse floatsWeb2 days ago · Cancer remains the main cause of human death worldwide, and most cancers still lack effective prevention and treatment means [].In recent years, immune checkpoint (ICP) blockade and targeted drug therapy have greatly improved the therapeutic effect of cancer patients, but there are still problems such as limited patient benefit and difficulty … port of peri peri sugar land txWebNational Center for Biotechnology Information iron horse home inspectionWebSep 15, 2024 · Identification of cancer-specific CTCF binding patterns in the human genome. a Distribution of coefficient of variation of chromatin accessibility at different genomic features, calculated using DNase-seq data from over 60 cell lines from ENCODE.b Distribution of occupancy score for all 688,429 union CTCF binding sites (blue), and … iron horse hobby shop closed