Determination of trilostane by hplc
WebJun 14, 1991 · The aim of the present study was therefore to develop a sensitive and specific HPLC assay method for the determination of plasma levels of trilostane and … http://jcore-reference.highwire.org/content/48/4/228
Determination of trilostane by hplc
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WebJun 1, 1991 · A simple high-performance liquid chromatographic (HPLC) method for assaying trilostane, a synthetic steroid, and one of its metabolites, ketotrilostane, in small volumes of rat plasma has been developed. A single liquid-liquid extraction was used to isolate the two compounds from acidified plasma prior to the quantitative analysis. WebA high-performance liquid chromatographic (HPLC) method for the determination of triclosan and triclocarban in cosmetic products was developed. Triclosan and triclocarban quantities in 168 of cosmetics were investigated and statistical analyzed with this method. The optimal condition are as follows: An Agilent SB-C8 analytical column (250 × 4. ...
WebWater samples were collected from each tank every 2–3 days (9/21 days in total) and trilostane concentrations in the water were measured by high-performance liquid chromatography (HPLC) with diode array detection (254 nm; Model 1100; Agilent Techologies, Santa Clara, CA). The HPLC was equipped with a Zorbax SB-C18 column … WebTrilostane inhibits synthesis of cortisol in dogs. It is a competitive inhibitor of 3-beta-hydroxysteroid dehydrogenate, which will interfere with the steps that lead to cortisol …
WebOct 17, 2016 · The method was validated and all the factors influencing the separation and analysis were checked experimentally. The method ensures the separation of the five above-mentioned compounds with good resolutions in a relatively short run time. Accordingly, the proposed HPLC method can be applied for in-process and finished … WebObjective: To determine whether trilostane or ketotrilostane is more potent in dogs and determine the trilostane and ketotrilostane concentrations that inhibit adrenal gland cortisol, corticosterone, and aldosterone secretion by 50%. Sample: 24 adrenal glands from 18 mixed-breed dogs. Procedures: Adrenal gland tissues were sliced, placed in tissue …
WebTrilostane has an IC 50 of ∼ 1.3 μM in inhibiting cortisol production from guinea pig dispersed adrenal cells stimulated with corticotrophin; ... A meta-analysis of 82 patients …
WebThus, plasma analysis is required to support in vivo studies in rats designed to maximise absorption. Two high-performance liquid chromatographic (HPLC) assays for trilostane … theory of multiple intelligences in educationtheory of multiple intelligences definitionWebA trilostane assay was developed using reagents and chemicals of high-performance liquid chromatography (HPLC) analytical grade. An Agilent 1260 Infinity HPLC system (Santa Clara, California) equipped with a pump (model G7111A), an auto sampler (model G7129A), Kinetex C18 (150 4.6 mm, 5 μm particle size) column (Torrance, Cali- theory of multiple intelligences quizWebGas chromatography (GC) and high-performance liquid chromatography (HPLC) coupled to different detectors, and in combination with different sample extraction methods, are most widely used for analysis of triazine herbicides in different environmental samples. Nowadays, many variations and modificati … shrunken pancreasWebThe Newcrom columns are a family of reverse phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups … shrunken leather motorcycle jacketWebBrown et al. 4 describe an HPLC method for the determination of Trilostane and its 17-keto analogue using a silica-based Partisil column and a silica-based Phenyl/Corasil … theory of multiple intelligences strengthsWebAug 15, 2024 · The determination of caffeine content in coffee products is routinely done by RPLC in commercial applications in order to guarantee purity and quality of ground … theory of multiple intelligences ppt