WebDec 27, 2024 · The most extensive clinical data on other PF-ILDs has come from the phase 3 INBUILD trial involving 663 patients. That work reported that nintedanib significantly slows disease progression, based on analysis of forced vital capacity (FVC) during 1 year. Whether the drug increases survival remains unclear. WebJul 29, 2024 · The primary analysis of the INBUILD trial showed that in subjects with progressive fibrosing interstitial lung diseases (ILDs), nintedanib slowed the decline in …
Nintedanib in patients with progressive fibrosing interstitial lung
WebN2 - Background: The INBUILD trial investigated the efficacy and safety of nintedanib versus placebo in patients with progressive fibrosing interstitial lung diseases (ILDs) other than idiopathic pulmonary fibrosis (IPF). We aimed to establish the effects of nintedanib in subgroups based on ILD diagnosis. WebINBUILD trial to investigate the efficacy and safety of nintedanib in patients with fibrosing intersti-tial lung diseases with a progressive phenotype. Methods Trial Design and Oversight lyrical therapy
Using Data on Survival with Idiopathic Pulmonary Fibrosis to
WebOct 1, 2024 · Here we report the Japanese subgroup analysis of the INBUILD trial in order to evaluate the consistency of the efficacy and safety of nintedanib in Japanese patients with progressive fibrosing ILDs compared with the overall INBUILD trial. 2. Materials and methods2.1. Study design WebSep 30, 2024 · The INBUILD trial was a randomized, double-blind, placebo-controlled, parallel group trial conducted at 153 sites in 15 countries that evaluated the efficacy and safety tolerability of nintedanib (150 mg, 2 x daily) over 52 weeks in … WebThe INBUILD trial was a randomised, double-blind, placebo-controlled, parallel group trial done at 153 sites in 15 countries.20 The trial was carried out in compliance with the protocol,20 the principles of the Declaration of Helsinki and the Harmonised Tripartite Guideline for Good Clinical Practice from the International Conference kirby cultural arts complex roxboro nc